Thursday, August 28, 2014

Health Benefits of Aspirin and Statins



Edited by Jonathan D. Kantrowitz

Published by Tsadek Press

Copyright, Jonathan Kantrowitz 2014


8.5 x 11, 154 pages
$12.95

Tsadek Press books $19.95
Tsadek Press books $24.95

Call 1-800-232--2224 to order a pdf of this title

Description:


Aspirin was considered a wonder drug when first discovered, but the latest research shows that aspirin is truly a wonder drug today. Prevention of heart attacks and strokes is just the beginning. Aspirin also works wonders in fighting many kinds of cancer. Aspirin slows or prevents cognitive declines as well. You need to read this book to learn about all these wonders, and many other benefits too numerous to mention, of regular aspirin consumption. 


Statins are prescribed to lower cholesterol in the US, but are available over the counter in Great Britain. Not only do statins prevent heart attacks, but, much like aspirin, they offer so many other benefits that they extend the life of their users significantly. 


Read all about it in this indispensable book!






Table of Contents



ASPIRIN

Heart Attack and Stroke Benefits       

Cancer Benefits                                                                      
            Breast and Ovarian Cancer                 
            Colorectal Cancer                   
            Pancreatic Cancer                   
            Prostate Cancer                      
            Skin Cancer                            
            Other Cancers                        
            All Cancers                             

Cognitive Decline/Dementia Benefits

Liver Disease/Damage Benefits          

Osteoporosis (Bone) Benefits              

Miscellaneous Benefits                      

Risks                                                  

STATINS



Benefit of Statins

Mortality                                                        
Cardiovascular                                                
Cancer                                                            
Parkinson's Disease                                       
Pneumonia                                                     
Gall Bladder Disease                                      




Miscellaneous Benefits                                  

Possible Negatives

Statins May Cause Muscle Problems             
Statins May Cause Diabetes                           
Statins May Cause Fatigue and Depression   
Statins May/May Not Increase Risk of Cataracts
More Negative Side Effects                            
Statins May Not Have Side Effects After All 
Coenzyme Q10 May Reduce Statin Risks     

Last Minute Additions  - Latest Research Reports

Aspirin
Statins
__________________________________________________________________________

Sample articles:

Bedtime aspirin may reduce risk of morning heart attack

Taking aspirin at bedtime instead of in the morning might reduce acute heart events, according a new study presented at the American Heart Association's Scientific Sessions 2013.

Low-dose daily aspirin is recommended for people at high risk of heart disease and for reducing the risk of recurrent heart events. Aspirin thins the blood and makes it less likely to clot. The tendency for platelet activity to be higher peaks in the morning.

The Aspirin in Reduction of Tension II trial is the first study to explore the timing of aspirin intake among cardiovascular disease patients. In the randomized, open-label study, 290 patients took either 100 mg of aspirin upon waking or at bedtime during two 3-month periods. At the end of each period, blood pressure and platelet activity was measured.

Blood pressure was not reduced; however, bedtime aspirin platelet activity was reduced by 22 units (aspirin reaction units).

"Because higher platelet activity contributes to a higher risk of acute heart events, this simple intervention – switching aspirin intake from morning to bedtime – could be beneficial for the millions of patients with heart disease who take aspirin on a daily basis," said Tobias Bonten, M.D., Ph.D student at the Leiden University Medical Center in the Netherlands.


Why Don't More Women Take a Daily Aspirin to Prevent Heart Disease?

Heart disease is the leading cause of death among women, and evidence-based national guidelines promote the use of daily aspirin for women at increased risk for cardiovascular disease. However, less than half of the women who could benefit from aspirin are taking it, according to an article in Journal of Women’s Health, a peer-reviewed publication from Mary Ann Liebert, Inc.

“Based on this survey, it is evident that the majority of women for whom aspirin is recommended for prevention of cardiovascular disease are not following national guidelines,” says Editor-in-Chief Susan G. Kornstein, MD.

Among more than 200,000 women participating in a web-based survey to assess their risk for cardiovascular disease, only 41%-48% of women for whom aspirin is recommended reported that they took an aspirin daily, according to the study authors, Cathleen Rivera, MD and Texas-based colleagues from Scott and White Healthcare, Navigant Healthcare Consultants, and Texas A&M Health Science Center.

The women were more likely to use aspirin if they had a family history of cardiovascular disease or had high cholesterol, as reported in the article “Underuse of Aspirin for Primary and Secondary Prevention of Cardiovascular Disease Events in Women.” The authors conclude that improved educational programs are needed to increase awareness of the benefits of aspirin use to prevent heart disease among women.


Aspirin: High or Low Dose? No significant difference in preventing recurring cardiovascular events

Researchers report no significant difference in high versus low dose aspirin in preventing recurring cardiovascular events.

Each year, more than one million Americans suffer a heart attack and nearly all patients are prescribed a daily aspirin and an antiplatelet medication during recovery. However, the optimal aspirin dose has been unclear. Now, new research from Brigham and Women's Hospital (BWH) reports that there is no significant difference between high versus low dose aspirin in the prevention of recurring cardiovascular events in patients who suffer from acute coronary syndromes (ACS), which are characterized by symptoms related to obstruction in coronary arteries, which supply blood to the heart. These findings were presented at the American College of Cardiology Scientific Sessions on March 24, 2012.

"We observed no difference between patients taking a high dose versus a low of aspirin as it relates to cardiovascular death, heart attack, stroke or stent thrombosis," said Payal Kohli, MD,cardiology fellow at BWH and researcher in the TIMI Study Group, who is the lead author on this study. "Interestingly, we did find a dramatic difference in practice patterns of physicians in North America compared to those in the rest of the world," Kohli said. "North American physicians prescribed a high dose of aspirin for two-thirds of all their patients, while the exact reverse was true of the rest of the world. International physicians prescribed a low dose of aspirin to more than two-thirds of their patients." Dr. Stephen D. Wiviott, a cardiologist at BWH and researcher in the TIMI Study Group, is the senior author on the study.

Researchers analyzed data from more than 11000 patients from around the world that were enrolled in the TRITON-TIMI 38 trial, which randomized ACS patients to receive either clopidigrel or prasugrel, two different antiplatelet medications. Some patients were prescribed high doses of aspirin following a heart attack, while others, low doses. The aspirin dose was prescribed at the clinician investigator's discretion and the analysis included 7,106 patients who received low dose aspirin, defined as 150 mg or less, and 4,610 patients who received high dose aspirin, defined as 150 mg or more. Researchers reported that there was no significant difference observed in the prevention of the combination of heart attack, stroke, cardiovascular death or the prevention of stent thrombosis between the groups that received high or low dose aspirin.


Wednesday, August 27, 2014

Neanderthals, Jews and The First Americans




Neanderthals, Jews and The First Americans

Edited by Jonathan D. Kantrowitz

Published by Tsadek Press

Copyright, Jonathan Kantrowitz 2014


8.5 x 11, 104 pages

$10.95


Tsadek Press books $19.95


Tsadek Press books $24.95


Call 1-800-232--2224 to order a pdf of this title


This book offers fascinating research reports on the background and genetic history of three groups of people with ancient origins  but, each in its own way, with an impact on our society today.




Topics Covered:


Neanderthals

Introduction                                                          
Neanderthals and Human Evolution                    
Appearance and Behavior                                       
Neanderthal Genes                                                 

Earliest Humans in Europe                                    
Interaction with Homo Sapiens                             
Extinction                                                                 

Jews

 Khazars                                                                 
Ashkenazi Jews                                                       

Sephardic Jews                                                        
Jews from North Africa                                          
All Jews                                                                    
Pashtuns                                                                   
Druze                                                                        

First Americans

Where They Came From                                        
When They Came                                                   
How They Lived                                                       
Who Are Their Descendants?                                
Life Before Columbus                                            
South America                                                         


Sample reports:


New Method Confirms Humans and Neandertals Interbred

Technical objections to the idea that Neandertals interbred with the ancestors of Eurasians have been overcome, thanks to a genome analysis method described in the April 2014 issue of the journal GENETICS. The technique can more confidently detect the genetic signatures of interbreeding than previous approaches and will be useful for evolutionary studies of other ancient or rare DNA samples.

“Our approach can distinguish between two subtly different scenarios that could explain the genetic similarities shared by Neandertals and modern humans from Europe and Asia,” said study co-author Konrad Lohse, a population geneticist at the University of Edinburgh.
The first scenario is that Neandertals occasionally interbred with modern humans after they migrated out of Africa. The alternative scenario is that the humans who left Africa evolved from the same ancestral subpopulation that had previously given rise to the Neandertals.

Many researchers argue the interbreeding scenario is more likely, because it fits the genetic patterns seen in studies that compared genomes from many modern humans. But the new approach completely rules out the alternative scenario without requiring all the extra data, by using only the information from one genome each of several types: Neandertal, European/Asian, African and chimpanzee.

The same method will be useful in other studies of interbreeding where limited samples are available. “Because the method makes maximum use of the information contained in individual genomes, it is particularly exciting for revealing the history of species that are rare or extinct,” said Lohse. In fact, the authors originally developed the method while studying the history of insect populations in Europe and island species of pigs in South East Asia, some of which are extremely rare.

Lohse cautions against reading too much into the fact that the new method estimates a slightly higher genetic contribution of Neandertals to modern humans than previous studies. Estimating this contribution is complex and is likely to vary slightly between different approaches.

“This work is important because it closes a hole in the argument about whether Neandertals interbred with humans. And the method can be applied to understanding the evolutionary history of other organisms, including endangered species,” said Mark Johnston, Editor-in-Chief of the journal GENETICS.

 

Jews



Khazars


 

Did the Khazars convert to Judaism? New research says 'no'


Did the Khazars convert to Judaism? The view that some or all Khazars, a central Asian people, became Jews during the ninth or tenth century is widely accepted. But following an exhaustive analysis of the evidence, Hebrew University of Jerusalem researcher Prof. Shaul Stampfer has concluded that such a conversion, "while a splendid story," never took place.

Prof. Shaul Stampfer is the Rabbi Edward Sandrow Professor of Soviet and East European Jewry, in the department of the History of the Jewish People at the Hebrew University's Mandel Institute of Jewish Studies. The research has just been published in the Jewish Social Studies journal, Vol. 19, No. 3 (online at http://bit.ly/khazars).

From roughly the seventh to tenth centuries, the Khazars ruled an empire spanning the steppes between the Caspian and Black Seas. Not much is known about Khazar culture and society: they did not leave a literary heritage and the archaeological finds have been meager. The Khazar Empire was overrun by Svyatoslav of Kiev around the year 969, and little was heard from the Khazars after. Yet a widely held belief that the Khazars or their leaders at some point converted to Judaism persists.

Reports about the Jewishness of the Khazars first appeared in Muslim works in the late ninth century and in two Hebrew accounts in the tenth century. The story reached a wider audience when the Jewish thinker and poet Yehudah Halevi used it as a frame for his book The Kuzari.

Little attention was given to the issue in subsequent centuries, but a key collection of Hebrew sources on the Khazars appeared in 1932 followed by a little-known six-volume history of the Khazars written by the Ukrainian scholar Ahatanhel Krymskyi. Henri Gregoire published skeptical critiques of the sources, but in 1954 Douglas Morton Dunlop brought the topic into the mainstream of accepted historical scholarship with The History of the Jewish Khazars.

Arthur Koestler's best-selling The Thirteenth Tribe (1976) brought the tale to the attention of wider Western audiences, arguing that East European Ashkenazi Jewry was largely of Khazar origin. Many studies have followed, and the story has also garnered considerable non-academic attention; for example, Shlomo Sand's 2009 bestseller, The Invention of the Jewish People, advanced the thesis that the Khazars became Jews and much of East European Jewry was descended from the Khazars. But despite all the interest, there was no systematic critique of the evidence for the conversion claim other than a stimulating but very brief and limited paper by Moshe Gil of Tel Aviv University.

Stampfer notes that scholars who have contributed to the subject based their arguments on a limited corpus of textual and numismatic evidence. Physical evidence is lacking: archaeologists excavating in Khazar lands have found almost no artifacts or grave stones displaying distinctly Jewish symbols. He also reviews various key pieces of evidence that have been cited in relation to the conversion story, including historical and geographical accounts, as well as documentary evidence. Among the key artifacts are an apparent exchange of letters between the Spanish Jewish leader Hasdai ibn Shaprut and Joseph, king of the Khazars; an apparent historical account of the Khazars, often called the Cambridge Document or the Schechter Document; various descriptions by historians writing in Arabic; and many others.

Taken together, Stampfer says, these sources offer a cacophony of distortions, contradictions, vested interests, and anomalies in some areas, and nothing but silence in others. A careful examination of the sources shows that some are falsely attributed to their alleged authors, and others are of questionable reliability and not convincing. Many of the most reliable contemporary texts, such as the detailed report of Sallam the Interpreter, who was sent by Caliph al-Wathiq in 842 to search for the mythical Alexander's wall; and a letter of the patriarch of Constantinople, Nicholas, written around 914 that mentions the Khazars, say nothing about their conversion.

Citing the lack of any reliable source for the conversion story, and the lack of credible explanations for sources that suggest otherwise or are inexplicably silent, Stampfer concludes that the simplest and most convincing answer is that the Khazar conversion is a legend with no factual basis. There never was a conversion of a Khazar king or of the Khazar elite, he says.

Years of research went into this paper, and Stampfer ruefully noted that "Most of my research until now has been to discover and clarify what happened in the past. I had no idea how difficult and challenging it would be to prove that something did not happen."

In terms of its historical implications, Stampfer says the lack of a credible basis for the conversion story means that many pages of Jewish, Russian and Khazar history have to be rewritten. If there never was a conversion, issues such as Jewish influence on early Russia and ethnic contact must be reconsidered.

Stampfer describes the persistence of the Khazar conversion legend as a fascinating application of Thomas Kuhn's thesis on scientific revolution to historical research. Kuhn points out the reluctance of researchers to abandon familiar paradigms even in the face of anomalies, instead coming up with explanations that, though contrived, do not require abandoning familiar thought structures. It is only when "too many" anomalies accumulate that it is possible to develop a totally different paradigm -- such as a claim that the Khazar conversion never took place.

Stampfer concludes, "We must admit that sober studies by historians do not always make for great reading, and that the story of a Khazar king who became a pious and believing Jew was a splendid story." However, in his opinion, "There are many reasons why it is useful and necessary to distinguish between fact and fiction -- and this is one more such case."


New study sheds light on the origin of the European Jewish population

Despite being one of the most genetically analysed groups, the origin of European Jews has remained obscure. However, a new study published)in the journal Genome Biology and Evolution by Dr Eran Elhaik, a geneticist at the Johns Hopkins School of Public Health, argues that the European Jewish genome is a mosaic of Caucasus, European, and Semitic ancestries, setting to rest previous contradictory reports of Jewish ancestry. Elhaik's findings strongly support the Khazarian Hypothesis, as opposed to the Rhineland Hypothesis, of European Jewish origins. This could have a major impact on the ways in which scientists study genetic disorders within the population.

The Rhineland Hypothesis has been the favoured explanation for the origins of present-day European Jews, until now. In this scenario Jews descended from Israelite-Canaanite tribes left the Holy Land for Europe in the 7th century, following the Muslim conquest of Palestine. Then, in the beginning of the 15th century, a group of approximately 50,000 left Germany, the Rhineland, for the east. There they maintained high endogamy, and despite wars, persecution, disease, plagues, and economic hardships, their population expanded rapidly to around 8 million in the 20th century. Due to the implausibility of such an event, this rapid expansion was explained by Prof Harry Ostrer, Dr Gil Atzmon, and colleagues as a miracle. Under the Rhineland Hypothesis, European Jews would be very similar to each other and would have a predominant Middle Eastern ancestry.

The rival explanation, the Khazarian Hypothesis, states that the Jewish-convert Khazars – a confederation of Turkic, Iranian, and Mongol tribes who lived in what is now Southern Russia, north of Georgia and east of Ukraine, and who converted to Judaism between the 7th and 9th centuries – along with groups of Mesopotamian and Greco-Roman Jews, formed the basis of eastern Europe's Jewish population when they fled eastward, following the collapse of their empire in the 13th century. European Jews are thus expected to exhibit heterogeneity between different communities. While there is no doubt that the Judeo-Khazars fled into Eastern Europe and contributed to the establishment of Eastern European Jewry, argument has revolved around the magnitude of that contribution.

Dr Elhaik's paper, 'The missing link of Jewish European ancestry: contrasting the Rhineland and the Khazarian Hypotheses', examined a comprehensive dataset of 1,287 unrelated individuals of 8 Jewish and 74 non-Jewish populations genotyped over 531,315 autosomal single nucleotide polymorphisms (SNPs). This was data published by Doron Behar and colleagues in 2010, which Elhaik used to calculate seven measures of ancestry, relatedness, admixture, allele sharing distances, geographical origins, and migration patterns. These identified the Caucasus-Near Eastern and European ancestral signatures in the European Jews' genome along with a smaller, but substantial Middle Eastern genome.

The results were consistent in depicting a Caucasus ancestry for all European Jews. The analysis showed a tight genetic relationship between European Jews and Caucasus populations and pinpointed the biogeographic origin of the European Jews to the south of Khazaria, 560 kilometers from Samandar –Khazaria's capital city. Further analyses yielded a complex multi-ethnical ancestry with a slightly dominant Caucasus -Near Eastern, large South European and Middle Eastern ancestries, and a minor Eastern European contribution.

Dr Elhaik writes, "The most parsimonious explanation for our findings is that Eastern European Jews are of Judeo-Khazarian ancestry forged over many centuries in the Caucasus. Jewish presence in the Caucasus and later Khazaria was recorded as early as the late centuries BCE and reinforced due to the increase in trade along the Silk Road, the decline of Judah (1st-7th centuries), and the rise of Christianity and Islam. Greco-Roman and Mesopotamian Jews gravitating toward Khazaria were also common in the early centuries and their migrations were intensified following the Khazars' conversion to Judaism… The religious conversion of the Khazars encompassed most of the Empire's citizens and subordinate tribes and lasted for the next 400 years until the invasion of the Mongols. At the final collapse of their empire in the 13th century, many of the Judeo-Khazars fled to Eastern Europe and later migrated to Central Europe and admixed with the neighbouring populations."

Dr Elhaik's findings consolidate, otherwise conflicting results describing high heterogeneity among Jewish communities and relatedness to Middle Eastern, Southern European, and Caucasus populations that are not explained under the Rhineland Hypothesis. Although Dr Elhaik's study linked European Jews to the Khazars, there are still questions to be answered. How substantial is the Iranian ancestry in modern day Jews? Since Eastern European Jews arrived from the Caucasus, where did Central and Western European Jews come from? If there was no mass migration out of Palestine at the 7th century, what happened to the ancient Judeans?

And crucially for Dr Elhaik, how would these new findings affect disease studies on Jews and Eurasian populations?

"Epidemiologists studying genetic disorders are constantly struggling with questions regarding ancestry, heterogeneity, and how to account for them," he says. "I hope this work will open up a new era in genetic studies where population stratification will be used more correctly."


The Lost Capital of the (Jewish) Khazars

A Russian archaeologist says he has found the lost capital of the Khazars, a powerful nation that adopted Judaism as its official religion more than 1,000 years ago, only to disappear leaving little trace of its culture.

Dmitry Vasilyev, a professor at Astrakhan State University, said his nine-year excavation near the Caspian Sea has finally unearthed the foundations of a triangular fortress of flamed brick, along with modest yurt-shaped dwellings, and he believes these are part of what was once Itil, the Khazar capital.

By law Khazars could use flamed bricks only in the capital, Vasilyev said. The general location of the city on the Silk Road was confirmed in medieval chronicles by Arab, Jewish and European authors.

"The discovery of the capital of Eastern Europe's first feudal state is of great significance," he told The Associated Press. "We should view it as part of Russian history."

Kevin Brook, the American author of "The Jews of Khazaria," e-mailed Wednesday that he has followed the Itil dig over the years, and even though it has yielded no Jewish artifacts, "Now I'm as confident as the archaeological team is that they've truly found the long-lost city,

The Khazars were a Turkic tribe that roamed the steppes from Northern China to the Black Sea. Between the 7th and 10th centuries they conquered huge swaths of what is now southern Russia and Ukraine, the Caucasus Mountains and Central Asia as far as the Aral Sea.

Itil, about 800 miles south of Moscow, had a population of up to 60,000 and occupied 0.8 square miles of marshy plains southwest of the Russian Caspian Sea port of Astrakhan, Vasilyev said.

It lay at a major junction of the Silk Road, the trade route between Europe and China, which "helped Khazars amass giant profits," he said.

The Khazar empire was once a regional superpower, and Vasilyev said his team has found "luxurious collections" of well-preserved ceramics that help identify cultural ties of the Khazar state with Europe, the Byzantine Empire and even Northern Africa. They also found armor, wooden kitchenware, glass lamps and cups, jewelry and vessels for transporting precious balms dating back to the eighth and ninth centuries, he said.

But a scholar in Israel, while calling the excavations interesting, said the challenge was to find Khazar inscriptions.

"If they found a few buildings, or remains of buildings, that's interesting but does not make a big difference," said Dr. Simon Kraiz, an expert on Eastern European Jewry at Haifa University. "If they found Khazar writings, that would be very important."

Vasilyev says no Jewish artifacts have been found at the site, and in general, most of what is known about the Khazars comes from chroniclers from other, sometimes competing cultures and empires.

"We know a lot about them, and yet we know almost nothing: Jews wrote about them, and so did Russians, Georgians, and Armenians, to name a few," said Kraiz. "But from the Khazars themselves we have nearly nothing."

The Khazars' ruling dynasty and nobility converted to Judaism sometime in the 8th or 9th centuries. Vasilyev said the limited number of Jewish religious artifacts such as mezuzas and Stars of David found at other Khazar sites prove that ordinary Khazars preferred traditional beliefs such as shamanism, or newly introduced religions including Islam.

Yevgeny Satanovsky, director of the Middle Eastern Institute in Moscow, said he believes the Khazar elite chose Judaism out of political expediency — to remain independent of neighboring Muslim and Christian states. "They embraced Judaism because they wanted to remain neutral, like Switzerland these days," he said.

In particular, he said, the Khazars opposed the Arab advance into the Caucasus Mountains and were instrumental in containing a Muslim push toward eastern Europe. He compared their role in eastern Europe to that of the French knights who defeated Arab forces at the Battle of Tours in France in 732.

The Khazars succeeded in holding off the Arabs, but a young, expanding Russian state vanquished the Khazar empire in the late 10th century. Medieval Russian epic poems mention Russian warriors fighting the "Jewish Giant."

"In many ways, Russia is a successor of the Khazar state," Vasilyev said.

He said his dig revealed traces of a large fire that was probably caused by the Russian conquest. He said Itil was rebuilt following the fall of the Khazar empire, when ethnic Khazars were slowly assimilated by Turkic-speaking tribes, Tatars and Mongols, who inhabited the city until it was flooded by the rising Caspian Sea around the 14th century.

The study of the Khazar empire was discouraged in the Soviet Union. The dictator Josef Stalin, in particular, detested the idea that a Jewish empire had come before Russia's own. He ordered references to Khazar history removed from textbooks because they "disproved his theory of Russian statehood," Satanovsky said.

Only now are Russian scholars free to explore Khazar culture. The Itil excavations have been sponsored by the Russian-Jewish Congress, a nonprofit organization that supports cultural projects in Russia.


"Khazar studies are just beginning," Satanovsky said.