Prostate Cancer - Latest Research Reports
Edited by Jonathan Kantrowitz
Published by Tsadek Press
Copyright 2014 Jonathan Kantrowitz
Call 1-800-232--2224 to order a pdf of this title
8.5 x 11, 114 pages
$10.95
2 Tsadek Press books $19.95
3 Tsadek Press books $24.95
2 Tsadek Press books $19.95
3 Tsadek Press books $24.95
Call 1-800-232--2224 to order a pdf of this title
The table of contents tells the complete story:
Introduction
Avoiding Prostate Cancer
Increased Prostate Cancer Risk
Screening for Prostate Cancer
Watchful
Waiting
Chemotherapy
Gene Therapy
Hormone Therapy
Supplemental
Therapies
Aspirin
Coffee
Statins
Diet and Exercise
Radiation
Surgery
Prostate
Cancer Survivorship
Last
Minute Additions – Latest Research
Appendix- Bladder Cancer
Increased Risk Of Bladder Cancer
Fighting Bladder Cancer
Treatment For Bladder Cancer
Sample articles:
Aspirin reduces
risk of prostate cancer mortality
Experimental
evidence suggests that anticoagulants (ACs) may inhibit cancer growth and
metastasis, but clinical data have been limited. This studyinvestigated whether
use of ACs was associated with the risk of death from prostate cancer.
This
study, published online Aug. 27, 2012 in the Journal of Clinical Oncology., comprised 5,955 men in the Cancer of
the Prostate Strategic Urologic Research Endeavor database with localized
adenocarcinoma of the prostate treated with radical prostatectomy (RP) or radiotherapy
(RT). Of them, 2,175 (37%) were receiving ACs (warfarin, clopidogrel,
enoxaparin, and/or aspirin). The risk of prostate cancer-specific mortality
(PCSM) was compared between the AC and non-AC groups.
AC
therapy, particularly aspirin, was associated with a reduced risk of PCSM in
men treated with RT or RP for prostate cancer. The association was most
prominent in patients with high-risk disease.
Aspirin reduces
the risk of cancer recurrence in prostate cancer patients
Some
studies have shown that blood-thinning medications, such as aspirin, can reduce
biochemical failure––cancer recurrence that is detected by a rising
prostate-specific antigen (PSA) level––the risk of metastasis and even death in
localized prostate cancer. These studies, although very telling, have all
emphasized the need for more data. Now, with researchers at Fox Chase Cancer
Center having concluded the largest study on this topic, and there is
substantial data suggesting that aspirin improves outcomes in prostate cancer
patients who have received radiotherapy.
A
team led by Mark Buyyounouski, M.D., M.S., a radiation oncologist at Fox Chase,
examined a database of over 2000 prostate cancer patients who underwent
radiotherapy at Fox Chase between 1989 and 2006 and found that aspirin use
lowers the risk of cancer recurrence. The scientists presented their findings
on Sunday, May 1, 2011 at the 93rd Annual Meeting of the American Radium
Society.
The
team found that the 761 men who took aspirin at or after the time of
radiotherapy were less likely to experience biochemical failure––as indicated
by the levels of PSA––than were the 1380 men who didn't take the drug.
After
10-years from completion of treatment, 31% of the men who took aspirin
developed recurrence compared with 39% of non-aspirin users (p=0.0005). There
was also a 2% improvement in 10-year prostate cancer related survival
associated with aspirin use with a trend toward statistical significance
(p=0.07). "We know that prostate cancer has a long natural history and 15
years or more may be necessary to detect significant difference in
survival," Dr. Buyyounouski explains. "Longer follow-up is needed,
but these results warrant further study."
The
readily available drug could be a promising supplement to radiotherapy in prostate
cancer patients, and its beneficial effects may generalize to other types of
cancer, Buyyounouski says. Still, he cautions that "it's a little
premature to say that men need to start taking aspirin if they have a history
of prostate cancer."
The
optimal dose, timing, and duration of aspirin therapy, as well as potential
side effects are not well understood, Buyyounouski explains. It's not clear how
exactly the aspirin is helping and more research is needed to investigate this.
"Its possible aspirin therapy is making the radiation more effective or
preventing the cancer from spreading".
Coffee
Four or more
cups of coffee a day may keep prostate cancer recurrence and progression away
Coffee
consumption is associated with a lower risk of prostate cancer recurrence and
progression, according to a new study by Fred Hutchinson Cancer Research Center
scientists in Cancer Causes &
Control.
Corresponding
author Janet L. Stanford, Ph.D., co-director of the Program in Prostate Cancer
Research in the Fred Hutch Public Health Sciences Division, conducted the study
to determine whether the bioactive compounds in coffee and tea may prevent
prostate cancer recurrence and delay progression of the disease.
Stanford
and colleagues found that men who drank four or more cups of coffee per day
experienced a 59 percent reduced risk of prostate cancer recurrence and/or
progression as compared to those who drank only one or fewer cups per week.
They
did not, however, find an association between coffee drinking and reduced
mortality from prostate cancer, although the study included too few men who
died of prostate cancer to address that issue separately.
First
study to assess the link between tea and prostate cancer outcomes
Regarding
tea consumption, the researchers did not find an associated reduction of
prostate cancer recurrence and/or progression. The study also did not draw any
conclusions regarding the impact of tea drinking on prostate-specific death.
“To
our knowledge, our study is the first to investigate the potential association
between tea consumption and prostate cancer outcomes,” the authors wrote. “It
is important to note, however, that few patients in our cohort were regular tea
drinkers and the highest category of tea consumption was one or more cups per
day. The association should be investigated in future studies that have access
to larger populations with higher levels of tea consumption.”
The
population-based study involved 1,001 prostate cancer survivors, aged 35-74
years old at the time of diagnosis between 2002-2005, who were residents of
King County, Wash. Participants answered questions regarding their diet and
beverage consumption two years prior to prostate cancer diagnosis using a
validated food frequency questionnaire, and were interviewed about demographic
and lifestyle information, family history of cancer, medication use and
prostate cancer screening history.
The
researchers followed up with patients more than five years after diagnosis to
ascertain whether the prostate cancer had recurred and/or progressed. Those who
were still living, willing to be contacted and had been diagnosed with
non-metastatic cancer were included in the follow-up effort.
Of
the original 1,001 patients in the cohort, 630 answered questions regarding
coffee intake, fit the follow-up criteria and were included in the final
analysis. Of those, 61 percent of the men consumed at least one cup of coffee
per day and 12 percent consumed the highest amount: four or more cups per day.
The
study also evaluated daily coffee consumption in relation to prostate
cancer-specific death in 894 patients using data from the initial food
frequency questionnaire. After the median follow-up period of eight-and-a-half
years, 125 of the men had died, including 38 specifically from prostate cancer.
Daily coffee consumption was not associated with prostate cancer-specific
mortality or other-cause mortality, but with few deaths these analyses were
limited.
“Our
study differs from previous ones because we used a composite definition of
prostate cancer recurrence/progression,” said first author Milan Geybels, a
doctoral student at Maastricht University in the Netherlands who was a graduate
student in Stanford’s Prostate Studies group at Fred Hutch when the study was
conducted. “We used detailed information on follow-up prostate-specific antigen
levels, use of secondary treatment for prostate cancer and data from scans and
biopsies to assess occurrence of metastases and cause-specific mortality during
follow up. Using these detailed data, we could determine whether a patient had
evidence of prostate cancer recurrence or progression.”
The
results are consistent with findings from Harvard’s Health Professionals
Follow-up Study, which found that men who drank six or more cups of coffee per
day had a 60 percent decreased risk of metastatic/lethal prostate cancer as
compared to coffee abstainers.
Further
research is required to understand the mechanisms underlying the results of the
study, but biological activities associated with consumption of phytochemical
compounds found in coffee include anti-inflammatory and antioxidant effects and
modulation of glucose metabolism. These naturally occurring compounds include:
Caffeine,
which has properties that inhibit cell growth and encourage apoptosis, or programmed
cell death. Previous studies have found that caffeine consumption may reduce
the risk of several cancer types, including basal-cell carcinoma, glioma (a
cancer of the brain and central nervous system) and ovarian cancer.
Additional
studies needed to confirm whether coffee can prevent cancer recurrence
The
researchers emphasize that coffee or specific coffee components cannot be
recommended for secondary prevention of prostate cancer before the preventive
effect has been demonstrated in a randomized clinical trial. Further, there’s
ongoing debate about which components in coffee are anti-carcinogenic, and
additional large, prospective studies are needed to confirm whether coffee
intake is beneficial for secondary prevention.
Coffee
drinking may even be problematic for some men, Geybels said.
“Although
coffee is a commonly consumed beverage, we have to point out that increasing
one’s coffee intake may be harmful for some men. For instance, men with
hypertension may be vulnerable to the adverse effects of caffeine in coffee.
Or, specific components in coffee may raise serum cholesterol levels, posing a
possible threat to coronary health. Patients who have questions or concerns
about their coffee intake should discuss them with their general practitioner,”
he said.
No comments:
Post a Comment